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WHOs First Guidance: a Significant Milestone In December 2025, the World Health Organization issued its first-ever guidance on GLP-1 medications for obesity a major moment in global clinical policymaking

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The treatment effects of interest, including the differences in the respective primary endpoints of interest from baseline to the defined primary timepoint, will be summarized using an analysis of covariance (ANCOVA) for the treatment regimen estimand and a mixed model for repeated measures (MMRM) for the efficacy estimand, both with treatment and strata as fixed effects and the baseline response variable as a covariate

But data from this study and others highlight the fact that it also improves overall cardiovascular risk and lowers the risk of non-cardiovascular events. Dr

Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans